Clinical trial · Interventional
Early Lung Cancer Diagnosis in HIV Infected Population With an Important Smoking History With Low Dose CT: a Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Early Lung Cancer diagnosis in a HIV-infected population with an important smoking history with low-dose CT: a pilot study: the HIV-CHEST study Objectives The main objective of this study is to evaluate the prevalence of lung cancers detected by low-dose computed tomography (CT) in a HIV-infected population with an important smoking history. Other objectives are (1) the evaluation of the types of lung cancers in this population, as well as (2) the staging of non small cell lung cancers, (3) the description of risk factors for all lung cancers, if they are numerous enough, and (4) the number of complications of diagnosis procedures during the study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hiv Infection | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low dose computed tomography (CT) | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- CT screening
- description
- CT interpretations and lung biopsies are guided by a suggested workup algorithm, which is not imposed in each HIV-caring centre
- interventionNames
- Radiation: Low dose computed tomography (CT)
Primary outcomes (1)
- measure
- the prevalence of lung cancers detected by lowdose computed tomography
- timeFrame
- Month 0
Secondary outcomes (4)
- measure
- the types of lung cancers in this population,
- timeFrame
- Month 1 Month 3 Month 12 Month 24 Month 26
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 40 years * able to give written consent * HIV positive serology * Covered by French Social Security * Nadir L TCD4 \< 350/µl * Rate of LTCD4 \> 100/µl at inclusion * Addiction to smoking \> 20 packages years, active person or deprived since \< 3 years Exclusion Criteria: * patients who suffered from comorbidity * unaffiliated to the social healthy security french system * Presence of an evolutionary cancer * any evolutionary pathology classifying AIDS * Pregnancy * Recent lung infection (\< 2 months) * Be under protection (saving) of justice
References
Publications (1)
- RESULTMakinson A, Eymard-Duvernay S, Raffi F, Abgrall S, Bommart S, Zucman D, Valour F, Cheret A, Poizot-Martin I, Duvivier C, Mauboussin JM, Bonnet F, Tattevin P, Reynes J, Le Moing V; ANRS EP48 HIV CHEST study Team. Feasibility and efficacy of early lung cancer diagnosis with chest computed tomography in HIV-infected smokers. AIDS. 2016 Feb 20;30(4):573-82. doi: 10.1097/QAD.0000000000000943. PMID 26829006