Clinical trial · Observational
Presence of Circulating Tumor DNA in Colorectal Cancer
Search for the Presence of Genetic Alteration in the Plasma of Patients With Stage II-III Colorectal Cancers: Prognosis Impact
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cancer is a DNA disease characterized by the presence of genetics alterations in cancer cells. The recent studies underline that these recurring alterations must be considered as a good molecular marker. In fact, they could use for tumor DNA detection in different biological fluids. So, the main purpose is to define the presence of circulating tumor DNA in the patients plasma with colorectal cancer, by the presence of mutation (KRAS, NRAS, BRAF, APC, TP53 and MIRCOSATELLIE instability). These molecular analysis will be done both in tumor and plasma samples, This trial allows to characterize the prognostic value of circulating tumoral DNA presence in colorectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- local recidivism or metastasis reappearance
- timeFrame
- 6 months after operation
Secondary outcomes (1)
- measure
- specificity and global safety
- timeFrame
- 36 monhs after operation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * patients aged Superior to 18 and inferior to 85 * Colon or rectal cancer stage II and III should be surgically treated * informed consent signed Exclusion Criteria: * patients suffered from synchronous metastasis disease in initial cancer diagnosis * patients with 2 synchronous colorectal cancers * receiving chemotherapy or radiotherapy, before operation
References
Publications (0)
Data not yet available