Clinical trial · Observational
Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma (HCC)
Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Results of liver transplantation, the best theoretical treatment for HCC, are limited by tumor recurrence. In order to limit this risk Milan criteria was proposed in 1996. However, these criteria are to restrictive and approximately 40% of patients denied by Milan criteria may be cured by liver transplantation. The purpose of this study was thus to prospectively evaluate factors predicting tumor recurrence after liver transplantation for HCC and then to reassess criteria for liver transplantation.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Evidence of Liver Transplantation | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Cirrhosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| search of factors predicting tumor recurrence | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- HCC patients
- description
- Patients notified on the national waiting list for hepatic transplant
- interventionNames
- Other: search of factors predicting tumor recurrence
Primary outcomes (1)
- measure
- Predictive factors of HCC recurrence
- timeFrame
- at 2 years after Liver transplantation for HCC (modified by amendment on 17/10/2013)
Secondary outcomes (5)
- measure
- Predictive factors of tumor-free recurrence
- timeFrame
- at 3 years
- measure
- Predictive factors of overall survival at 5 years
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Liver cirrhosis * Hepatocellular carcinoma diagnosed by AASLD criteria or liver biopsy * Listing for Liver transplantation for HCC fulfilling or not Milan criteria * No extra-hepatic spread * No vascular involvement Exclusion Criteria: * Salvage transplantation * Transplantation contra-indication * Evaluation for Liver transplantation older than 1 month * Incidental HCC
References
Publications (0)
Data not yet available