Clinical trial · Observational
Racial and Genetic Biomarkers of Response in Tissue Samples From Patients With Endometrial Cancer
The Relationship of Racial Genetic Admixture With Endometrial Cancer Outcomes
NCT01198171CI-TRIAL-00079819completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study is studying racial and genetic biomarkers of response in tissue samples from patients with endometrial cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. DNA analysis of tumor tissue may also help doctors predict how well patients will respond to treatment.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Stage III Uterine Corpus Cancer | Malignant Uterine Corpus Neoplasm | CURATED_BROADER | 0.78 |
| Stage II Uterine Corpus Cancer | Malignant Uterine Corpus Neoplasm | CURATED_BROADER | 0.78 |
| Stage I Uterine Corpus Cancer | Malignant Uterine Corpus Neoplasm | CURATED_BROADER | 0.78 |
| Stage IV Uterine Corpus Cancer | Malignant Uterine Corpus Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
| Study of Socioeconomic and Demographic Variables | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Basic science (DNA analysis)
- description
- DNA from archived frozen normal tissue samples is genotyped for the ancestry informative markers. Clinicopathological and demographic characteristics associated with each sample are also collected.
- interventionNames
- Other: Laboratory Biomarker Analysis
- Other: Study of Socioeconomic and Demographic Variables
Primary outcomes (4)
- measure
- Clinicopathologic and demographic characteristics: characteristics: self-reported race, stage, age, race, parity, body-mass index, stage, grade, depth of invasion, lymph-vascular space invasion, and metastasis
- timeFrame
- 1 year
- measure
- Overall survival
- timeFrame
- 1 year
- measure
- Progression-free survival
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed endometrial cancer * Stage I-IV disease regardless of grade * Underwent surgical staging including hysterectomy, bilateral oophorectomy, washings, and pelvic lymphadenectomy * Eligible and evaluated on GOG-0210 clinical trial, a Molecular Staging Study in Endometrial Cancer * Available frozen or formalin-fixed and paraffin-embedded normal tissue that is free of tumor cells and yields sufficient high-quality normal DNA for testing * Consented their specimens and clinical data to be collected and used in future studies * Self-declared African-American or Caucasian race
References
Publications (0)
Data not yet available
No reference posted for this study.