Clinical trial · Interventional
The Use of Light Therapy for Managing Sleep Disturbances in Patients With Advanced Cancer
NCT01193530CI-TRIAL-00037811terminatedPhase 2 / Phase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Low Accrual
Summary
Brief summary (as posted)
The goal of this research study is to learn if a type of light therapy can be used to help patients with advanced cancer who are having difficulty sleeping to sleep better.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Cancers | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bright Light Litebook | Device | — | UNRESOLVED |
| Bright Light Therapy | Other | — | UNRESOLVED |
| Dim Red Light Therapy | Other | — | UNRESOLVED |
| Questionnaires | Behavioral | — | UNRESOLVED |
| Red Light Litebook | Device | — | UNRESOLVED |
| Study Diaries | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Bright Light Therapy
- description
- Daily Bright Light Therapy using Bright Light Litebook device for two 14 day periods.
- interventionNames
- Other: Bright Light Therapy
- Behavioral: Questionnaires
- Behavioral: Study Diaries
- Device: Bright Light Litebook
- type
- PLACEBO_COMPARATOR
- label
- Dim Red Light Therapy
- description
- Daily Dim Red Light Therapy (placebo) using control Red Light Litebook device for 14 days then proceed to the open label phase and receive daily bright light for 14 days.
- interventionNames
- Other: Dim Red Light Therapy
- Behavioral: Questionnaires
- Behavioral: Study Diaries
- Device: Red Light Litebook
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Advanced cancer patients seen in Supportive Care outpatient clinic at M.D. Anderson Cancer Center, with average sleep disturbance \>=4 out of 10 for at least one week 2. Age 18 or greater 3. Karnofsky performance status score of \>=40 at time of inclusion into study 4. Agrees to return to MD Anderson Cancer Center (MDACC) for follow-up visits 5. English speaking Exclusion Criteria: 1. Persons with congenital blindness and self-reported acquired blindness (independent of the cause) with no light perception 2. Patients with a history of retinal disease 3. Patients with a current diagnosis of major depression disorder or generalized anxiety disorder 4. Patients who have received light therapy in the past either as part of treatment for other disorders or as a study subject 5. Patients currently on amiodarone, thiazide diuretics or epidermal growth factor receptor (EGFR) inhibitors (erlotinib, gefitinib, cetuximab, panitumumab) 6. Patients who are currently receiving ultraviolet A light/ultraviolet B light (UVA/UVB) therapy or tanning sessions at salons 7. Patients with a diagnosis of obstructive sleep apnea or narcolepsy 8. Patients with \>2 hours of direct exposure to outdoor natural light per day (light exposure diary -- screening).
References
Publications (0)
Data not yet available
No reference posted for this study.