Clinical trial · Observational
Studies Examining the Importance of Smoking After Being Diagnosed With Lung Cancer
Does Smoking Status After Being Diagnosed With Lung Cancer Influence Outcome? An Observational Cohort Study.
NCT01192256CI-TRIAL-00060088LungCastcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A large project consisting of: a) an observational trial where smoking status is recorded on 1400 consecutive people newly diagnosed with lung cancer. Smoking status is biologically validated with exhaled carbon monoxide (eCO) levels every 3 months. Survival, cancer progression and treatment complications will be recorded and compared in smokers, ex-smokers and never smokers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Median and 2-year survival rates in confirmed smokers versus non- smokers newly diagnosed with lung cancer.
- timeFrame
- 24 months
Secondary outcomes (6)
- measure
- Median survival and 2-year survival rates by smoking status for early (Stage I/II NSCLC) versus those with advanced (Stage III/IV) NSCLC.
- timeFrame
- 24 months
- measure
- Number of treatment complications in smokers versus non-smokers (frequency surgical wound complications, radiotherapy induced pneumonitis and median total radiation (Gy) dose; frequency and duration of neutropenic sepses
- timeFrame
- 2 years
- measure
- Point prevalence of smoking at 0, 3, 6 12, 24 months
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * clinical diagnosis of lung cancer Exclusion Criteria: * refusal Consent * inability to provide exhaled CO * active psychiatric illness or substance misuse * concurrent malignancies of another type other than non-melanoma skin cancer * unable to travel for sessions with smoking cessation counsellor and / or outpatient visits from outset * WHO performance status 4 * Life expectancy less than 6 weeks.
References
Publications (4)
- RESULTGemine RE, Ghosal R, Collier G, Parry D, Campbell I, Davies G, Davies K, Lewis KE; LungCast Investigators. Longitudinal study to assess impact of smoking at diagnosis and quitting on 1-year survival for people with non-small cell lung cancer. Lung Cancer. 2019 Mar;129:1-7. doi: 10.1016/j.lungcan.2018.12.028. Epub 2018 Dec 28. PMID 30797485
- DERIVEDGemine RE, Davies GR, Lewis KE; LungCAST Investigators. Quitting Smoking and Two-Year Survival After a Diagnosis of Small-Cell Lung Cancer. Clin Lung Cancer. 2026 Jun 27;27(7):18-23. doi: 10.1016/j.cllc.2026.06.006. Online ahead of print. PMID 42480249
- DERIVEDGemine RE, Davies GR, Lanyon K, Rees SE, Campbell I, Lewis KE; LungCAST Investigators. Quitting smoking improves two-year survival after a diagnosis of non-small cell lung cancer. Lung Cancer. 2023 Dec;186:107388. doi: 10.1016/j.lungcan.2023.107388. Epub 2023 Oct 1. PMID 37820539
- DERIVEDJones M, Lowin J, Sewell B, Gemine RE, Rees SE, Lanyon K, Lewis KE. The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non-Small Cell Lung Cancer. Value Health. 2023 Aug;26(8):1192-1200. doi: 10.1016/j.jval.2023.03.2429. Epub 2023 Apr 12. PMID 37059391