Clinical trial · Observational
Short Non-coding RNA Biomarkers of Predisposition to Ovarian Cancer
A Pilot Study of Short Non-coding RNA Biomarkers of Predisposition to Ovarian Cancer
NCT01187602CI-TRIAL-00016259sncRNAunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to create new tests to identify biomarkers for ovarian cancer so that a screening test can be developed. For patients who have a diagnosis of ovarian Cancer, researchers will use blood samples before and after treatment to see if disease status can be determined by measuring the amount of biomarker.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (3)
- label
- Women at average risk for ovarian cancer
- description
- Women at average risk for ovarian cancer (no first degree relatives with breast or ovarian cancer) undergoing gynecologic evaluation at UVA for non-malignant or routine indications.
- label
- Women with ovarian cancer
- description
- Women with known or suspected ovarian cancer who are undergoing evaluation and/or treatment at UVA Cancer Center
- label
- Increased risk for ovarian cancer
- description
- Women at increased risk of ovarian cancer based on family history, personal history, or genetic factors defined as either BRCA1 or BRCA2 mutations who still retain both fallopian tubes and both ovaries.
Primary outcomes (2)
- measure
- Defining sncRNA alterations associated with hereditary predisposition to ovarian cancer
- timeFrame
- 24 months
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Undergoing medical care at UVA * Up to date breast cancer screening * Subjects must fall into one of the following groups: * Women at increased risk of ovarian cancer based on family history, personal history, or genetic factors defined as either BRCA1 or BRCA2 mutations who still retain both fallopian tubes and both ovaries. * Women at average risk for ovarian cancer * Women with known/suspected or recurrent ovarian cancer who are undergoing evaluation and/or treatment at UVA Cancer Center Exclusion Criteria: * Subjects with increased risk for ovarian cancer may not have a history of prior malignancy within the last 10 years excluding cervical carcinoma in situ or basal cell carcinoma * Pregnancy (self reported)
References
Publications (0)
Data not yet available
No reference posted for this study.