Clinical trial · Interventional
Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial
NCT01179724CI-TRIAL-00003770unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
after endoscopic submucosal dissection(ESD) of early gastric cancer, conventional proton pump(PPI) inhibitors and H2 receptor antagonists have a controversial effect on preventing bleeding from artificial ulcers. the aim of this study was to investigate whether a stronger acid suppression (high dose PPI) more effectively prevents bleeding after ESD
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Delayed Bleeding | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| H2RB | Drug | — | UNRESOLVED |
| high dose proton pump inhibitor | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- high dose proton pump inhibitor
- interventionNames
- Drug: high dose proton pump inhibitor
- type
- ACTIVE_COMPARATOR
- label
- H2 receptor antagonist
- interventionNames
- Drug: H2RB
Primary outcomes (1)
- measure
- bleeding incidence after ESD
- timeFrame
- time to occur delayed bleeding within one month after ESD
Secondary outcomes (1)
- measure
- the size of healing ulcer after ESD
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * the patients who agreed informed consent * gastric adenoma or early gastric cancer which is eligible for conventional ESD indication Exclusion Criteria: * recent drug history of PPI, H2 rector antagonist, bismuth and antibiotics within 4 weeks * recent drug history of anticoagulant or antiplatelet agent within 7 days * s/p subtotal gastrectomy * recurred gastric adenoma or cancer * pregnant or breast feeding patients
References
Publications (0)
Data not yet available
No reference posted for this study.