Trientine and Carboplatin in Advanced Malignancies

Inclusion Criteria:

1. Patient must have an advanced malignancy that has either failed one or more prior therapies, or for whom there is no established standard of care therapy that prolongs survival by at least 3 months.
2. Only in 1 of 3 expansion cohorts, we will plan to enroll 14 subjects with platinum-resistant malignancy. Patient with platinum-resistant malignancy is defined to have had a treatment-free interval of less than 6 months following a platinum-based regimen.
3. Patient of any age and any gender. However, those who are 12 years old or younger will be eligible after consultation with their pediatric physicians regarding dose initiation and modification of trientine.
4. Patient has an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
5. Patient is willing to comply with study procedures and follow-up examinations.
6. Patient or primary care taker must be informed of the investigational nature of this study and must sign and give written Institutional Review Board (IRB)-approved informed consent in accordance with institutional guidelines.
7. If patient is of childbearing potential, she or he must agree to practice an effective method of birth control prior to study entry, for the duration of study participation, and for 30 days after the last study dose.
8. Patient has adequate organ functions: serum bilirubin \</= 2.0 mg/dL; ALT \</= 3 x upper limit of normal (ULN), or ALT \</= 5 x ULN if the patient has hepatic metastasis; serum creatinine \</= 1.5 mg/dL or a calculated creatinine clearance of at least 60 mL/min.
9. Patient has adequate bone marrow reserve: absolute neutrophil count (ANC) \>/= 1,500 /ul, Platelet count \>/= 100,000 /ul , and Hemoglobin \>/= 9.0 g/dL.

Exclusion Criteria:

1. Patient receiving any concurrent chemotherapy.
2. Underlying medical condition that might be aggravated by treatment or that cannot be controlled, such as active, uncontrolled, serious infection and cardiac dysfunction.
3. Medical and/or psychiatric problems of sufficient severity to limit full compliance with the study or expose patients to undue risk.
4. Known anaphylactic or severe hypersensitivity to study drugs or their analogs.
5. Patient has failed to recover from any prior surgery within 4 weeks of study entry.
6. Patient is pregnant or lactating.
7. Patient has had any treatment specific for tumor control within 3 weeks of dosing with investigational drugs and cytotoxic agents, or within 2 weeks of cytotoxic agent given weekly, or within 6 weeks of nitrosoureas or mitomycin C, or within 5 half-lives of biological targeted agents with half-lives and pharmacodynamic effects lasting less than 5 days (that includes, but is not limited to, erlotinib, sorafenib, sunitinib, bortezomib, and other similar agents), or failure to recover from the toxic effect of any of these therapies prior to study entry.
8. Patient has any signs of intestinal obstruction interfering with nutrition.
9. Patient has a known history of central nervous system (CNS) metastasis unless the patient has had treatment with surgery or radiation therapy, and is neurologically stable.
10. Patient is not able to swallow oral medication.
11. Patient has clinical evidence of copper deficiency (i.e. ceruloplasmin level was less than 15 mg/dL or free serum copper level less than 2.2 ug/dL).