Clinical trial · Interventional
Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum
Does Hemodynamic Optimization During and After Colorectal Surgery Result in Improved Intestinal Perfusion, Sustained Intestinal Barrier and Improved Postoperative Recovery?
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on in- or decrease of the output of the heart. Between group differences are measured primarily by markers of intestinal damage in plasma and urine. Also CO2 pressure in the stomach lumen is measured (reflecting blood supply to the gut). The investigators hypothesize that the intervention group will have less intestinal damage, improved blood supply to the bowel and improved recovery of the operation compared to the control group.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Goal-directed fluid optimization | Procedure | — | UNRESOLVED |
| Regimen based on expertise anaesthesist | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Goal-directed fluid optimization
- description
- Fluid administration and optimization based on cardiac output findings during surgery and during the first 8 hours of the postoperative phase.
- interventionNames
- Procedure: Goal-directed fluid optimization
- type
- OTHER
- label
- Regimen based on expertise anaesthesist
- description
- Fluid regimen based on expertise anaesthesist
- interventionNames
- Other: Regimen based on expertise anaesthesist
Primary outcomes (1)
- measure
- Peak Value of I-FABP
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients undergoing elective colorectal surgery with anastomosis; * Minimum age 18 years; * Giving informed consent. Exclusion Criteria: * Other causes of intestinal damage: eg. IBD, occlusive disease; * Steroid use; * Esophageal varices and other esophageal disease; * Aortic valve disease.
References
Publications (0)
Data not yet available