Clinical trial · Interventional
Ability of a New Design of Iodine 125 Seed to Maintain Intended Position When Implanted in the Prostate
A Study Assessing the Ability of AnchorSeed Iodine-125 Sources to Hold Fast in Tissue When Implanted for Treatment of Localized Prostate Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compares the ability of a new design of brachytherapy seed for prostate seed implants for treatment of prostate cancer to maintain their intended position in the prostate after being deposited. Standard seeds, especially in apical locations, have a tendency to migrate distally in response to muscular forces. AnchorSeeds have a textured coating which is designed to prevent migration. 40 patients who are eligible and suitable for prostate brachytherapy will be randomly assigned to receive either standard seeds or AnchorSeeds.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| AnchorSeed Iodine 125 brachytherapy prostate implant | Radiation | — | UNRESOLVED |
| Iodine 125 standard loose brachytherapy seeds | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Standard loose Iodine 125 seeds
- description
- Prostate brachytherapy implant to be performed with standard format loose Iodine 125 seeds
- interventionNames
- Radiation: Iodine 125 standard loose brachytherapy seeds
- type
- EXPERIMENTAL
- label
- AnchorSeed Iodine 125 implant
- description
- Prostate brachytherapy implant to be performed with a new design of Iodine 125 seed that has a coating to increase adherence to tissue
- interventionNames
- Radiation: AnchorSeed Iodine 125 brachytherapy prostate implant
Primary outcomes (1)
- measure
- seed displacement
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * localized prostate cancer * favorable or intermediate risk * suitable for permanent seed implant by functional and technical criteria Exclusion Criteria: * patient unwilling to have a second CT scan for study purposes * claustrophobic patient unable to have CT scan * patient unsuitable for brachytherapy because of prostate size or poor voiding function * patient medically unable to stop anticoagulants for procedure
References
Publications (1)
- BACKGROUNDBadwan HO, Shanahan AE, Adams MA, Shanahan TG, Mueller PW, Markwell SJ, Tarter TH. AnchorSeed for the reduction of source movement in prostate brachytherapy with the Mick applicator implant technique. Brachytherapy. 2010 Jan-Mar;9(1):23-6. doi: 10.1016/j.brachy.2009.07.002. Epub 2009 Sep 17. PMID 19762286