Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor

Inclusion Criteria:

* Histologically confirmed brain tumors (glioblastoma multiforme, anaplastic astrocytoma, medullo
* Age 0 through 17 years (pediatric subjects), and 18 years and above (adult subjects)
* Lansky score of ≥ 60 (0-15 years) or Karnofsky (16 years or older) performance score of ≥ 60%
* Adequate organ function within 14 days of study registration including the following:

  * Adequate bone marrow reserve: absolute neutrophil (segmented and bands) count (ANC) ≥ 1.0 x 10\^9/L, platelets ≥100 x 10\^9/L; hemoglobin ≥ 8 g/dL
  * Hepatic: bilirubin ≤1.3 mg/dL or 0-22 mmol/L, aspartate transaminase (AST) and alanine transaminase (ALT) \< 3 x upper limit of normal (ULN)
  * Renal: Normal serum creatinine for age (below) or creatinine clearance \>60 ml/min/1.73 m\^2.
* Sexually active women of child bearing potential must agree to use adequate contraception (diaphragm, birth control pills, injections, intrauterine device \[IUD\], surgical sterilization, subcutaneous implants, or abstinence, etc.) for the duration of the vaccination period. Sexually active men must agree to use barrier contraceptive for the duration of the vaccination period.
* Willingness to travel to participate in study if from outside local region.
* Voluntary written informed consent must be obtained from all patients (if of assent age) and their parents or legal guardians before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.

Exclusion criteria:

* Pregnant or breast-feeding. Pregnancy testing will be performed on all menstruating females within 14 days of study enrollment.
* Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness/social situations that would limit compliance with study requirements.
* Currently receiving any other investigational agents.
* History of immune system abnormalities such as hyperimmunity (e.g., autoimmune diseases) and hypoimmunity (e.g., myelodysplastic disorders, marrow failures, AIDS, ongoing pregnancy, transplant immuno-suppression).
* Any conditions that could potentially alter immune function (e.g., AIDS, multiple sclerosis, diabetes, renal failure).