Clinical trial · Interventional
Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors
Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors.
NCT01155258CI-TRIAL-00022559completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vinorelbine ditartrate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving temsirolimus together with vinorelbine ditartrate may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of giving temsirolimus and vinorelbine ditartrate together in treating patients with unresectable or metastatic solid tumors.
Conditions
Conditions (48)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Extensive Stage Small Cell Lung Cancer | Lung Small Cell Carcinoma | CURATED_BROADER | 0.78 |
| Hereditary Paraganglioma | Hereditary Paraganglioma | ONTOLOGY_EXACT | 0.98 |
| Male Breast Cancer | Male Breast Carcinoma | ALIAS | 0.90 |
| Malignant Paraganglioma | — | UNRESOLVED | — |
| Metastatic Gastrointestinal Carcinoid Tumor | Digestive System Neuroendocrine Tumor G1 | CURATED_BROADER | 0.78 |
| Metastatic Pheochromocytoma | Adrenal Gland Pheochromocytoma | CURATED_BROADER | 0.78 |
| Pancreatic Polypeptide Tumor | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| temsirolimus | Drug | Temsirolimus | ALIAS |
| vinorelbine ditartrate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Arm I
- description
- Patients receive temsirolimus IV over 30-60 minutes on days 1, 8, 15, and 22 and vinorelbine ditartrate IV over 5-10 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
- interventionNames
- Drug: temsirolimus
- Drug: vinorelbine ditartrate
Primary outcomes (2)
- measure
- To determine the maximum tolerated dose of Temsirolimus and Vinorelbine
- timeFrame
- 1 month up to 18 months
- measure
- To assess the response rate based on the Response Evaluation Criteria in Solid Tumors (RECIST)
- timeFrame
- 2 months up to 18 months
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion * Patients with histologically confirmed metastatic or unresectable solid tumors for which standard curative measures do not exist or are no longer effective; histology will be limited to those tumors for which temsirolimus or vinorelbine have reported clinical activity: lung, breast, ovary, cervix, prostate, uterus, renal, bladder and neuroendocrine tumors * SWOG performance status of 0-2 * Projected life expectancy of at least 3 months * Provision of informed consent prior to any study-related procedures * Negative pregnancy test for women of childbearing potential * Female patients must not be pregnant due to the potential mutagenicity and teratogenicity of this treatment; a pregnancy test must be administered 7 days prior to administration of therapy to women of childbearing potential; patients must agree to use some form of contraception while on this study at initiation and for the duration of participation in the study; sexually active males must also use a reliable and appropriate method of contraception; post-menopausal women must be amenorrheic for at least 12 months to be considered of nonchildbearing potential * Patients must have recovered from acute toxicities from previous surgery, chemotherapy or radiation therapy * ANC \>= 1500/mm\^3 * Platelet count \>= 100,000 cells/mm\^3 * Hemoglobin \>= 9.0g/dL * Serum creatinine =\< 1.5 mg/dl * Hepatic function: Patients must have adequate liver functions: AST or ALT =\< 2.5 X upper limit of normal (ULN), alkaline phosphatase =\< 2.5 X upper limit of normal; in patients with bone metastasis and no evidence of liver metastasis and bilirubin =\< upper limit of normal an alkaline phosphatase =\< 5 ULN will be allowed * Serum Bilirubin =\< 1.0 mg/dL * Peripheral neuropathy grade 0-1 * No other concomitant therapy directed at the cancer is allowed Exclusion * Prior therapy with vinorelbine or an mTor inhibitor * Receipt of any investigational agents within 30 days prior to commencing study treatment * Last dose of prior chemotherapy discontinued less than 4 weeks before the start of study therapy * Last radiation therapy within the last 4 weeks before the start of study therapy, except palliative radiotherapy * Any unresolved toxicity greater than CTC grade 1 from previous anticancer therapy, excluding alopecia * CTC Grade 1 or greater neuropathy (motor or sensory) at study entry * Hematologic function with absolute neutrophils =\< 1500/mm\^3 and/or platelets \< 100,000/mm\^3 * Hepatic function with serum bilirubin greater than the upper institutional limits of normal, ALT and AST \> 2.5 times the upper institutional limits of normal * Concurrent use of strong inhibitors of CYP3A4: ketoconazole, itraconazole, ritonavir, amprenavir, indinavir, nelfinavir, delavirdine and voriconazole * CYP3A4 inducers should be avoided or used with caution; the use of these agents is discouraged: rifabutin, rifampicin, rifapentine, carbamazepine, Phenobarbital, phenytoin and St. John's wart * Ongoing long term use of steroids for chronic conditions
References
Publications (0)
Data not yet available
No reference posted for this study.