Physical Functional Side Effects of Taxane Chemotherapy for Breast Cancer

Inclusion Criteria:

* Women 21-70 years old (Women over 70 are offered chemotherapy less frequently because of their risk benefit ratio. Including them would be a selection bias because of their differential underexposure).
* Initiated taxane-based chemotherapy in the neoadjuvant, adjuvant, or previously untreated metastatic setting.
* The range of exposure to taxane-based chemotherapy will include women on active treatment having received two cycles, to women who are within three months of their last infusion.
* Documented symptoms of CIPN per CTCAE grading criteria (half of sample) or NO symptoms (half of sample) Grade 0 = no CIPN symptoms Grade 1 = mild symptoms Grade 2 = moderate symptoms - prescribed Gabapentin (Neurontin) Grade 3\&4= severe symptoms - treated with Gabapentin (Neurontin), treatment plan altered

Exclusion Criteria:

* Physical disabilities - defined by use of assistive devices to complete functional tasks (wheelchair, crutches, prosthetic limbs) prior to starting chemotherapy.
* Current exposure to neurotoxic agents (Navelbine, platinums or other taxanes)
* Pregnancy during chemotherapy treatment
* Diabetes - diagnosed 3 or more years , or insulin dependent, or with clinically established neuropathy
* Previous exposure to chemotherapy or radiotherapy
* HIV positive (high risk for neuropathy)
* Other neurological diseases, such as Multiple Sclerosis
* Other pre-existing neuropathy