Clinical trial · Observational
Study of Episodic Breathlessness in Patients With Lung Cancer or Other Advanced Disease
Experiences of Episodic Breathlessness (EB) in Patients With Advanced Disease
NCT01138358CI-TRIAL-00011884completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Gathering information about experiences of episodic breathlessness in patients with advanced disease may help doctors learn more about the disease. PURPOSE: This clinical trial is studying experiences of episodic breathlessness in patients with lung cancer or other advanced disease.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dyspnea | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Metastatic Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| medical chart review | Other | — | UNRESOLVED |
| quality-of-life assessment | Procedure | — | UNRESOLVED |
| study of socioeconomic and demographic variables | Other | — | UNRESOLVED |
| survey administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Experiences of episodic breathlessness
- measure
- Impact of episodic breathlessness on daily living
- measure
- Individual coping strategies to reduce burden of episodic breathlessness
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Diagnosis of advanced disease as defined by the following criteria:
* Lung cancer
* Primary lung cancer at all stages (small cell lung cancer \[SCLC\] and non-small cell lung cancer \[NSCLC\])
* Cancer at any site with secondary tumor of the lung (lung metastasis)
* Chronic obstructive pulmonary disease (COPD)
* Stage III or IV of the Global Initiative for Obstructive Lung Disease (GOLD) classification, which includes the airflow limitation measured by spirometry FEV1 \< 50%, FEV1/FVC \< 0.7, and symptoms such as more severe breathlessness, reduced exercise capacity, and repeated exacerbations
* Chronic heart failure (CHF)
* NYHA class II-IV heart disease, which includes symptoms such as dyspnea or palpitation and an increasing limitation of exercise capacity or discomfort at rest
* Motor neuron disease (MND)
* All patients suffering from breathlessness
* Suffering from episodic breathlessness as defined above at any level of severity
PATIENT CHARACTERISTICS:
* Able to give informed consent
* Able to be interviewed
* No cognitive impairment (clinically judged by the principal investigator)
* No limited comprehension of the English language
PRIOR CONCURRENT THERAPY:
* Concurrent disease-oriented therapies (e.g., chemotherapy, radiotherapy, or surgery) allowedReferences
Publications (1)
- DERIVEDSimon ST, Niemand AM, Benalia H, Voltz R, Higginson IJ, Bausewein C. Acceptability and preferences of six different routes of drug application for acute breathlessness: a comparison study between the United Kingdom and Germany. J Palliat Med. 2012 Dec;15(12):1374-81. doi: 10.1089/jpm.2012.0249. Epub 2012 Oct 24. PMID 23094954