Clinical trial · Observational
Biomarkers in Blood Samples From Older Breast Cancer Survivors
The Effect of Chemotherapy on Aging in Older Women With Breast Cancer as Measured by Expression of p16INK4a
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors understand how well patients respond to treatment. PURPOSE: This research study is studying biomarkers in blood samples from older women with stage I, stage II, or stage III breast cancer who have finished primary therapy or breast cancer survivors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gene expression analysis | Genetic | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| medical chart review | Other | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
| reverse transcriptase-polymerase chain reaction | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Treatment w/Surgery
- description
- Breast Cancer survivors treated with surgery with or without radiation.
- interventionNames
- Genetic: gene expression analysis
- Genetic: reverse transcriptase-polymerase chain reaction
- Other: laboratory biomarker analysis
- Other: medical chart review
- Other: questionnaire administration
- label
- Treatment w/endocrine therapy
- description
- Breast Cancer survivors treated with surgery with or without radiation plus endocrine therapy.
- interventionNames
- Genetic: gene expression analysis
- Genetic: reverse transcriptase-polymerase chain reaction
- Other: laboratory biomarker analysis
- Other: medical chart review
- Other: questionnaire administration
- label
- Treatment w/ chemotherapy
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Histologically confirmed breast cancer
* Stage I-III disease
* Breast cancer survivors meeting 1 of the following criteria:
* Prior surgery with or without (±) radiotherapy (RT) (cohort 1)
* Prior surgery ± RT, followed by prior or concurrent hormonal (endocrine) therapy (cohort 2)
* Must have received or be on endocrine therapy for ≥ 3 months
* Prior surgery ± RT, followed by prior chemotherapy ± endocrine therapy (cohort 3)
* No recurrent disease
* No history of clonal bone marrow disorder (i.e., myelodysplastic or myeloproliferative disorder, acute or chronic leukemia)
PATIENT CHARACTERISTICS:
* Life expectancy \> 12 months
* Absolute lymphocyte count \> 500/μL
* No acute or active infection
* No other co-morbid illness that would impair ability to participate in the study
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* At least 3 months since prior surgery with or without radiotherapy
* At least 3 months since prior chemotherapy (cohort 3)
* No concurrent radiotherapy, chemotherapy, or experimental therapyReferences
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