A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Inclusion Criteria:

* Male and female patients aged over 18 years
* Histologically proven lung adenocarcinoma
* clinical stage IIIB/IV
* ECOG performance status 0-2
* Had no prior anticancer agent, radiation or surgical therapy for lung adenocarcinoma
* At least one measurable lesion (according to RECIST)
* Provision of written informed consent
* Life expectancy of at least 12 weeks

Exclusion Criteria:

* History of malignant disease.
* Evidence of clinically active interstitial lung diseases (patients with chronic, stable, radiographic changes who are asymptomatic need not be excluded)
* Expected life expectancy less than 2 months
* As judged by the investigator, any evidence of severe or uncontrolled systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic, or renal disease)
* Aspartate aminotransferase (AST/SGOT) or alanine aminotransferase (ALT/SGPT) ≥ 2.5 x ULN if no demonstrable liver metastases (or \>5 x in presence of liver metastases)
* Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the subject to participate in the study
* Pregnancy or breast-feeding women (women of child¬bearing potential). Women of childbearing potential must practice acceptable methods of birth control to prevent pregnancy.