A Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer

Inclusion Criteria:

* 18 years of age
* Pathologically confirmed metastatic pancreatic adenocarcinoma
* At least 1 radiologically evaluable metastatic lesion (RECIST 1.1).
* ECOG 0 or 1
* Life expectancy ≥3 months.
* All women of child bearing potential, all sexually active male patients, and partners of patients must agree to use adequate methods of birth control
* Ability to adhere to the study visit schedule
* Voluntarily signed an informed consent form

Exclusion Criteria:

* Islet cell, acinar cell carcinoma, non-adenocarcinoma, (i.e., lymphoma, sarcoma), adenocarcinoma originated from biliary tree or cystadenocarcinoma
* Prior treatment with chemotherapy for pancreatic cancer.
* Known central nervous system metastases
* Inadequate hematologic function
* Inadequate hepatic function
* Inadequate renal function
* External (percutaneous) biliary drain
* History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months.
* Venous thromboembolic event (e.g., pulmonary embolism or deep vein thrombosis) requiring anticoagulation not appropriately anticoagulated or have NCI CTCAE Grade 2 or greater bleeding episode in the 3 weeks prior to administration of IPI-926
* Concurrent administration of the medications or foods known to inhibit CYP3A activity to a clinically relevant degree
* Presence of active infection or systemic use of antibiotics within 72 hours of treatment
* Significant co-morbid condition or disease which in the judgment of the Investigator would place the patient at undue risk or interfere with the study.
* Known human immunodeficiency virus (HIV) positivity
* Known hypersensitivity to gemcitabine, IPI-926, or their excipients
* Pregnant or lactating women