Clinical trial · Observational
Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy
Multicenter Prospective Analysis of Treatment Outcome in Patients With Large Acoustic Neuromas
NCT01129687CI-TRIAL-00058387completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neuroma, Acoustic | Vestibular Schwannoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Microsurgery | Procedure | — | UNRESOLVED |
| Stereotactic radiation therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- ANSRS group
- description
- Patients qualifying for the study.
- interventionNames
- Procedure: Microsurgery
- Procedure: Stereotactic radiation therapy
Primary outcomes (1)
- measure
- Need for stereotactic radiation therapy should tumor remnant grow on annual MRI's
- timeFrame
- 10 years
Secondary outcomes (1)
- measure
- Facial nerve function measured on House-Brackmann scale
- timeFrame
- 10 y
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients with acoustic neuromas the widest diameter of 2.5 cm or larger at the cerebellopontine angle are eligible for this trial. * Patients that are deemed good surgical candidates based on age, general health, genetic predispositions, and hearing in contralateral side would be included as the subjects of this trial. * Although we would include patients with neurofibromatosis II in this trial, considering their genetic predisposition for recurrence, we would analyze their outcome as a separate group. Exclusion Criteria: * Patients who have received any form of treatment of their acoustic neuromas prior to enrollment in the study including surgery or radiation therapy.
References
Publications (0)
Data not yet available
No reference posted for this study.