Clinical trial · Interventional
Evaluation of 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Cancer.
Randomised Clinical Phase III Study of Radiotherapy Dose, Volume Evaluation for 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Squamous Cell Carcinoma
NCT01124409CI-TRIAL-00005077unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error verification.Also,the various dosimetric variations in Adaptive RT will be studied.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CARCINOMA LARYNX | — | UNRESOLVED | — |
| CARCINOMA OROPHARYNX | — | UNRESOLVED | — |
| CARCINOMA PYRIFORM SINUS | — | UNRESOLVED | — |
| HEAD AND NECK CANCER | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CBCT verification | Radiation | — | UNRESOLVED |
| EPID Verification | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- 3DCRT with EPID
- description
- this patients randomised to this arm will be planned by 3DCRT and during treatment setup error will be identified and corrected by weekly EPID if error \>3mm.Weekly CBCT will be done for this arm to note the setup error but will not be corrected.
- interventionNames
- Radiation: EPID Verification
- type
- ACTIVE_COMPARATOR
- label
- IGRT with CBCT
- description
- The patients randomised to this arm will be planned by 3DCRT and set up error during RT will be verified by CBCT and error corrected if \>3mm.Weekly EPID will be done for setup error documentation but no correction based on EPID in this arm.
- interventionNames
- Radiation: CBCT verification
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Histopathologically proven cases of Carcinoma Oropharynx,Larynx,Hypopharynx, stages T1-4 N0-2a M0 * Informed Consent * KPS score \> 70 Exclusion Criteria: * Uncontrolled medical comorbidity * Not ready for follow up * Previous cancer directed therapy
References
Publications (0)
Data not yet available
No reference posted for this study.