Clinical trial · Observational
Childhood Cancer Survivor Study
NCT01120353CI-TRIAL-00115122recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Cancer survivors
- description
- Survivors of cancer, diagnosed under 21 years of age, between 1970 and 1999 This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, for an increased risk of late-occurring events associated with excess mortality and morbidity.
- label
- Sibling Controls
- description
- A group of sibling controls will be identified to provide: (1) the ability to make direct comparisons with the survivors, (2) data on outcomes in a non-cancer population, and (3) additional comparison group to determine consistency of findings between data sources.
Primary outcomes (1)
- measure
- To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.
- timeFrame
- 25 years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: Initial Cohort: * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers. Expanded cohort: * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers. * English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis. Exclusion Criteria: * Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy. * Non-English speaking or residence outside the US or Canada. Sibling Controls: * For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.
References
Publications (9)
- DERIVEDWebster R, Chambers EO, Qiu W, Dhaduk R, Wang L, Yasui Y, Yuan Y, Nathan PC, Leisenring W, Armstrong GT, Howell R, Schulte T, Yalch M, Cordova M, Krull KR, Brinkman TM, Edelstein K. Neurocognitive impairment and substance use in adult survivors of childhood cancer: a cross-sectional analysis from the Childhood Cancer Survivor Study. EClinicalMedicine. 2026 Apr 29;95:103924. doi: 10.1016/j.eclinm.2026.103924. eCollection 2026 May. PMID 42094234
- DERIVEDMurphy AJ, Chen Y, Cameron DB, Geiger EJ, Ramsey D, Green DM, Howell RM, Kieran K, Krull KR, Meacham LR, Ness KK, Oeffinger KC, Yasui Y, Armstrong GT, Chow EJ, Weldon CB, Weil BR. Late complications of treatment for childhood pelvic sarcoma: A report from the Childhood Cancer Survivor Study (CCSS). J Pediatr Surg. 2026 Jul;61(7):163117. doi: 10.1016/j.jpedsurg.2026.163117. Epub 2026 Mar 30. PMID 41921603
- DERIVEDBashore L, Peterson RK, Li C, Liu W, Wang M, Jiwani ZM, McDonald AJ, Lupo PJ, King A, Srivastava D, Leisenring WM, Howell RM, Gibson TM, Oeffinger K, Armstrong GT, Bowman WP, Krull KR, Edelstein K. Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report. JCO Oncol Pract. 2026 Jul;22(7):1322-1330. doi: 10.1200/OP-25-00414. Epub 2025 Sep 8. PMID 40920992
- DERIVEDAlberts NM, Leisenring W, Whitton J, Stratton K, Jibb L, Flynn J, Pizzo A, Brinkman TM, Birnie K, Gibson TM, McDonald A, Ford J, Olgin JE, Nathan PC, Stinson JN, Armstrong GT. Characterization of chronic pain, pain interference, and daily pain experiences in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Pain. 2024 Nov 1;165(11):2530-2543. doi: 10.1097/j.pain.0000000000003284. Epub 2024 Jul 9. PMID 38981063
- DERIVEDWilson CL, Bjornard KL, Partin RE, Kadan-Lottick NS, Nathan PC, Oeffinger KC, Hayashi RJ, Hyun G, Armstrong GT, Leisenring WM, Howell RM, Yasui Y, Dixon SB, Ehrhardt MJ, Robison LL, Ness KK. Trends in physical functioning in acute lymphoblastic leukemia and non-Hodgkin lymphoma survivors across three decades. J Cancer Surviv. 2025 Apr;19(2):496-506. doi: 10.1007/s11764-023-01483-1. Epub 2023 Nov 8.