Clinical trial · Interventional
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women
Effect of Metformin With or Without Folate Addiction on Uterine Blood Flow and Trophoblastic Invasion in Pregnant Patients With Polycystic Ovary Syndrome
NCT01115140CI-TRIAL-00004911completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine (Hcy) levels in patients with PCOS, and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
| Pregnancy | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Metformin plus folic acid | Drug | — | UNRESOLVED |
| metformin plus placebo | Drug | — | UNRESOLVED |
| placebo alone | Drug | — | UNRESOLVED |
| placebo plus folic acid | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- type
- ACTIVE_COMPARATOR
- label
- Group A1
- description
- metformin plus placebo
- interventionNames
- Drug: metformin plus placebo
- type
- EXPERIMENTAL
- label
- Group A2
- description
- metformin plus folic acid
- interventionNames
- Drug: Metformin plus folic acid
- type
- ACTIVE_COMPARATOR
- label
- Group A3
- description
- placebo plus folic acid
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 38 Years
Show eligibility criteria text
Inclusion Criteria: * Pregnancy * PCOS Exclusion Criteria: * Risk factors for pregnancy complications * Severe obesity
References
Publications (0)
Data not yet available
No reference posted for this study.