Clinical trial · Interventional
Influence of Selenium on Prostate Cancer Related Biomarkers
NCT01112449CI-TRIAL-00018510completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Penn State Milton S. Hershey Medical Center researchers are trying to compare the effects of two different forms of selenium (selenium yeast and selenomethionine) on blood selenium levels and biomarkers of oxidative stress as primary endpoints. One in six men are at risk of getting prostate cancer in their lifetime. Participants will be asked to take over-the-counter selenium yeast supplements and selenomethionine or a placebo for nine out of twelve months.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Effect of Selenium on Oxidative Stress in Healthy Men | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| high dose selenized-yeast | Dietary Supplement | — | UNRESOLVED |
| low dose selenized-yeast | Dietary Supplement | — | UNRESOLVED |
| Placebo | Other | — | UNRESOLVED |
| selenomethionine | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Low dose selenized-yeast
- description
- 200 µg/day of selenized-yeast (SY)
- interventionNames
- Dietary Supplement: low dose selenized-yeast
- type
- EXPERIMENTAL
- label
- selenomethionine
- description
- The second group will receive 200 µg/day of selenomethionine (SM)
- interventionNames
- Dietary Supplement: selenomethionine
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- no active medication.
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 20 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * No history or evidence of diabetes * Male between the ages of 20-79 * PSA levels ≤ 4.0 ng/mL * Not taking \>50 µg/day selenium as a dietary supplement including multi- vitamins * Non-smoker * No concurrently participating or have participated in any other clinical trial within at least 30 days of registration * Health male Exclusion Criteria: * Evidence of prostate cancer * Evidence of liver or kidney disease
References
Publications (1)
- DERIVEDRichie JP Jr, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila). 2014 Aug;7(8):796-804. doi: 10.1158/1940-6207.CAPR-14-0042. Epub 2014 Jun 17. PMID 24938534