Feasibility Study of SOL (S-1,Oral Leucovorin,and Oxaliplatin) for Colorectal Cancer in China

Inclusion Criteria:

* Advanced unresectable or recurrent colorectal cancer patients which meet the following criteria:

  * Willing to sign ICF
  * Could orally take investigational product
  * Pathology diagnosis is adenocarcinoma
  * Above 20 years
  * No previous treatment(including: radiotherapy,chemotherapy and immunotherapy)
  * For recurrent cases, if the patient had received adjuvant chemotherapy that didn't include S-1 and L-OHP in 180 days ago, he/she could be enrolled in
  * With target lesions with diameter which is longer than 1cm in spiral CT or MRI examination within 30 days
* Lab test within 15 days meet following criteria

  * Hemoglobin higher than 9.0g/dL
  * Leukocyte higher than 12,000/mm3
  * Neutrophil higher than 2,000/mm3
  * PLT higher than 10.0 104/mm3
  * Bilirubin lower than 1.5 times of upper limit of normal range
  * AST,ALT,ALP lower than 2.5 times of upper limit of normal range
  * Creatinine lower than upper limit of normal range

When patient has liver metastasis or bone metastasis, the value of AST,ALT,ALP could be within 5 times of upper limit of normal range

* ECOG 0 or 1
* Expected survival time more than 90 days

Exclusion Criteria:

* The patient who meet the following criteria should be excluded from this trial
* Patients who have severe drug allergic history(including: platinum related drugs,5-FU,FT,LV,5-HT3 receptor antagonist)
* Attended other clinical trial within 4 weeks
* Received transfusion of blood,related products or G-CSF within 15 days
* Received surgery within 4 weeks and the effect hadn't vanished
* Have diarrhea
* Have complication of active infection(infection caused fever higher than 38℃)
* Have complication of poor controlled hypercalcemia,hypertension,diabetes
* Have complication of severe ECG abnormal or other heart disease which will affect clinical treatment(including: cardiac dysfunction,myocardial infarction,angina)
* Have complication of severe pulmonary disease(including:interstitial pneumonia,pulmonary fibrosis,severe emphysema)
* Have complication of psychiatric disorder which will affect clinical treatment or have history of CNS disease
* Have complication of active gastrointestinal bleeding
* Have pleural effusion,ascites or pericardial effusion that need drainage
* Have complication of multiple bone metastasis
* Have severe complication(including:ileus,renal insufficiency,hepatic insufficiency,cerebrovascular disturbance)
* Have brain metastasis or suspicious brain metastasis
* Have active multiple primary cancer
* Female patients who are in pregnancy or lactation and patients who are not willing to take contraception measures
* Investigator judge not eligible to this trial