Radiofrequency Ablation Combined With Chemotherapy for Pulmonary Tumors

Inclusion Criteria:

* adult (\> 18 years) male or female patient
* patient has biopsy-proven NSCLC or lung metastasis
* patient has been rejected for surgery and has been considered unfit for radiation therapy
* each 6 cm or smaller in greatest diameter of tumor, by CT scan
* tumors are located at least 1 cm from trachea; main bronchi; esophagus; aorta; aortic arch branches; pulmonary artery; and heart
* tumors are accessible by percutaneous route
* patient has Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
* patient has platelet count \> 100 x 109 /L and international normalized ratio ≤ 1.5
* patient has signed written informed consent prior to any study specific procedures.

Exclusion Criteria:

* patient is considered at high-risk for RF ablation due to major co-morbid medical conditions
* patient has more than 3 tumors / lung
* patient has at least one tumor \> 6 cm in greatest diameter
* tumor is associated with atelectasis or obstructive pneumonitis
* patient has renal failure requiring hemodialysis or peritoneal dialysis
* patient has active clinically serious infection
* patient has history of organ allograft
* patient has history of substance abuse or any medical, psychological or social conditions that may interfere with his / her participation in the study or evaluation of the study results
* patient is pregnant or breast-feeding
* patient has ECOG performance status \> 2
* patient has platelet count ≤ 100 x 109 /L or international normalized ratio \> 1.5.