Clinical trial · Observational
Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia
Sentinel Node Investigation in Patients With Highly Differentiated Papillary Thyroid Carcinoma and in Patients With Thyroid Neoplasia of Unclear Malignant Potential
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The standard surgical treatment for highly differentiated papillary thyroid cancer \> 10 mm according to recent national and international guidelines, is total thyroidectomy and central lymphnode clearance, and for patients with cytology indicating thyroid neoplasia of unclear malignant potential hemithyroidectomy on the side of the tumour. The study investigates if the sentinel lymphnode (SN) * Reliably (with high sensitivity and specificity), can predict the pathological findings of the lymphnodes in the central compartment in patients with highly differentiated papillary thyroid cancer * Is useful to aid in the final diagnosis and staging of thyroid neoplasias of unclear malignant potential, and could be used to select patients for further central lymphnode revision.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Thyroid Neoplasms | Thyroid Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Histological investigation of the SN | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Papillary thyroid cancer
- description
- Patients with preoperatively diagnosed highly differentiated papillary thyroid cancer
- interventionNames
- Procedure: Histological investigation of the SN
- label
- Tumour of uncertain malignant potential
- description
- Thyroid tumours with preoperative cytology indicating follicular neoplasia, or on cytology suspected but not proven malignancy
- interventionNames
- Procedure: Histological investigation of the SN
Primary outcomes (1)
- measure
- Sensitivity and specificity of SN histology compared with the final histology of the non SN central lymph nodes (metastasis or no metastasis)
- timeFrame
- 14 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with first time surgery for proven papillary thyroid cancer \> 10 mm * Patients with first time surgery for a cytologic diagnosis of follicular neoplasia or suspected (not proven) malignancy Exclusion Criteria: * Age below 18 years * Pregnancy or lactation * Inability to understand written and oral information or to comply with scheduled follow-up
References
Publications (0)
Data not yet available