Clinical trial · Interventional
A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
A Randomized Clinical Trial Examining the Efficacy of Treatment of Cutaneous Verruca Vulgaris in Adult Patients With Combined Liquid Nitrogen Cryotherapy and Topically Applied Cantharidin
NCT01084824CI-TRIAL-00003257completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Verruca Vulgaris | Verruca Vulgaris | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Liquid nitrogen and cantharidin | Drug | — | UNRESOLVED |
| Liquid nitrogen and topical placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Liquid nitrogen and canthardin
- description
- Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterwards.
- interventionNames
- Drug: Liquid nitrogen and cantharidin
- type
- PLACEBO_COMPARATOR
- label
- Liquid nitrogen and placebo
- description
- Liquid nitrogen applied to wart(s) then placebo vehicle afterwards.
- interventionNames
- Drug: Liquid nitrogen and topical placebo
Primary outcomes (1)
- measure
- Percentage of common warts cleared
- timeFrame
- 12 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. common warts on non-genital, non-facial skin 2. otherwise healthy 3. between 18-65 and able to give informed consent 4. capable of tolerating treatment Exclusion Criteria: 1. Ill-health 2. Poor tolerance or sensitivity to treatments in study 3. \<18 years old; \>65 years old 4. verruca plana or condyloma acuminata 5. immunosuppression or immune dysfunction 6. significant peripheral vascular disease 7. significant sensitivity to cold 8. epidermodysplasia verruciformis 9. mosaiform warts or periungual warts
References
Publications (3)
- BACKGROUNDBerth-Jones J, Bourke J, Eglitis H, Harper C, Kirk P, Pavord S, Rajapakse R, Weston P, Wiggins T, Hutchinson PE. Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol. 1994 Dec;131(6):883-6. doi: 10.1111/j.1365-2133.1994.tb08594.x. PMID 7857844
- BACKGROUNDGuidelines of care for cryosurgery. American Academy of Dermatology Committee on Guidelines of Care. J Am Acad Dermatol. 1994 Oct;31(4):648-53. No abstract available. PMID 8089292
- BACKGROUNDMoed L, Shwayder TA, Chang MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001 Oct;137(10):1357-60. doi: 10.1001/archderm.137.10.1357. PMID 11594862