Clinical trial · Observational
Pangenomic Study During Alcoholic Cirrhosis
Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis
NCT01065233CI-TRIAL-00053944CDCHCcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome. The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition. In this study, the investigators will identify predictives genetic polymorphism of HCC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Alcoholic Cirrhosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DNA extraction | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- alcoholic cirrhosis with viral infection
- description
- patient with alcoholic cirrhosis with viral infection (300 patients)
- interventionNames
- Genetic: DNA extraction
- label
- alcoholic cirrhosis without viral infection
- description
- patient with alcoholic cirrhosis without viral infection
- interventionNames
- Genetic: DNA extraction
Primary outcomes (1)
- measure
- Existence of HCC and Pangenomic analysis of DNA polymorphism
- description
- Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * 35 to 70 years old * Compensated cirrhosis or not * Caucasian origin of the parents * Patient with cirrhosis (histological proof or obvious) Exclusion Criteria: * HIV, HBV, HCV positive * Known Homozygotia (C282Y+/+) * Important hepatocytary iron overload for patient with resection * HCC non histologically prooved
References
Publications (1)
- DERIVEDArchambeaud I, Auble H, Nahon P, Planche L, Fallot G, Faroux R, Gournay J, Samuel D, Kury S, Feray C. Risk factors for hepatocellular carcinoma in Caucasian patients with non-viral cirrhosis: the importance of prior obesity. Liver Int. 2015 Jul;35(7):1872-6. doi: 10.1111/liv.12767. Epub 2015 Jan 21. PMID 25522809