Clinical trial · Observational
Assessment of Ovarian Reserve in Female Cancer Survivors
Fertility in Female Cancer Survivors - Novel Assessment of Ovarian Reserve
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy can damage the ovaries and cause premature menopause. In women treated before the age of 40 years, menopause does not usually occur. We have very little information about the impact of chemotherapy on ovarian function in this particular group of women. In this study, we will check hormone blood tests and ultrasound tests of the ovaries to measure the reserve of eggs left in the ovaries after treatment in young survivors of breast cancer and childhood cancer. We will do the same tests in our comparison group. We can use these results to estimate the reduction in fertility in young cancer survivors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer Survivor | — | UNRESOLVED | — |
| Pediatric Cancer Survivor | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Draw and Ultrasound | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Breast Cancer Survivors
- interventionNames
- Procedure: Blood Draw and Ultrasound
- label
- Pediatric Cancer Survivors
- interventionNames
- Procedure: Blood Draw and Ultrasound
- label
- Control group
- interventionNames
- Procedure: Blood Draw and Ultrasound
Primary outcomes (3)
- measure
- To estimate the immediate decline in ovarian reserve in young breast cancer patients receiving chemotherapy using new biochemical and biophysical measures
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Breast Cancer Survivors 1. histological confirmation of breast cancer 2. received chemotherapy +/- radiotherapy with curative intent 3. age 40 years or less at the time of diagnosis 4. currently age 50 years or less 5. currently disease free. * Pediatric Cancer Survivors 1. Received chemotherapy and / or radiotherapy with curative intent. 2. Currently age 18 years and older. 3. Currently premenopausal and attained at age 50 years or less. 4. Currently disease free. 5. Diagnosed with sarcoma or Hodgkin's disease or leukemia at 30 years or less. * Control group 1. Premenopausal. Exclusion Criteria: * Breast Cancer Survivors 1. treatment for malignancy other than breast cancer, involving chemotherapy or radiation to the ovaries/pelvis. 2. any cancer recurrence 3. hysterectomy/oophorectomy. * Pediatric Cancer Survivors 1. Hysterectomy / oophorectomy. 2. Pelvic Radiation. * Control group 1. Received chemotherapy and / or pelvic radiation therapy, 2. hysterectomy/oophorectomy.
References
Publications (0)
Data not yet available