Clinical trial · Observational
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps). The telomere length of peripheral blood lymphocytes (PBLs) can be measured from a blood sample. Mechanistic pathways and the investigator's preliminary data support PBL telomere length as a biomarker for ACPs. The long-term goal of this project is to decrease deaths from colon cancer by using a blood test to target colonoscopy for those patients who are at high risk for pre-cancerous polyps.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colonic Polyp | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- ACP (advanced colon polyp) Group
- description
- Between the ages of 50 and 60 years old and have an ACP (advanced colon polyp)
- label
- Control Group
- description
- Individuals between the ages of 50 and 60 years old who have had a negative screening colonoscopy.
Primary outcomes (1)
- measure
- Telomere length are shorter in individuals with colon polyps.
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: Advanced Colon Polyp Group (ACP): * Must be 50 to 60 years of age with an advanced colon polyp (ACP: advanced colon polyps are those larger than 10 mm, or a colon polyp with high grade dysplasia, or a colon polyp with villous features. Control Group (Controls): * Must be 50 to 60 years of age and have had a negative screening colonoscopy. * Controls will also have no history of adenomatous colorectal neoplasia. Exclusion Criteria: * Subjects under 50 years of age * Subjects over 60 years of age * Subjects with colon polyps less than 10 mm in size
References
Publications (0)
Data not yet available