Clinical trial · Interventional
Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No participants enrolled
Summary
Brief summary (as posted)
Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway. Current therapy is mainly surgical, but in a significant portion of patients adjuvant therapy is required to control the disease process. Although multiple adjuvant medical therapies have been tried, success has been limited. We have seen some success in a limited amount of patients using orally administered propranolol. Our goal is to enroll a larger cohort of patients to determine the effectiveness of propranolol as an adjuvant therapy for JORRP.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Respiratory Papillomatosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propranolol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Children treated with propranolol
- interventionNames
- Drug: Propranolol
Primary outcomes (1)
- measure
- Decreased number of surgeries
- timeFrame
- 3 months
Secondary outcomes (1)
- measure
- Improved voice quality
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 1 Year
- Maximum age
- 10 Years
Show eligibility criteria text
Inclusion Criteria: * 1\. Biopsy proven with appropriate Human Papilloma Virus typing Recurrent Respiratory Papilloma * 2\. Child under age 10 * 3\. Informed consent and where appropriate informed assent * 4\. Children who have undergone at least 4 documented surgical interventions in the past year. Exclusion Criteria: * Parental or child refusal to participate * Heart failure * Atrio-ventricular heart block * Cardiac anomalies * Low resting heart rate * Low resting blood pressure * Wolff-Parkinson White Syndrome * Unexplained syncope * Asthma or Reactive airway disease * Renal or liver failure * Expected long fasting periods, \>12 hours * Diabetes Mellitus * Hypersensitivity to propranolol
References
Publications (0)
Data not yet available