Clinical trial · Interventional
A Study of Gemcitabine and Cyberknife Radiation Therapy for Pancreatic Cancer
A Pilot Study of Full Dose Gemcitabine and Hypofractionated Stereotactic Radiosurgery in the Treatment of Unresectable Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
People with pancreatic cancer that cannot be cured by surgery are being asked to participate in this study. The purpose of this study is to test the ability of the radiation oncologists to administer Cyberknife therapy along with Gemcitabine chemotherapy for patients with pancreatic cancer. Radiation and Gemcitabine are both effective at killing cancer cells but they generally cannot be given at the same time. Cyberknife therapy is highly focused radiation that is being used extensively at Georgetown University and around the United States to treat a number of cancers. It is believed that because Cyberknife is so highly focused it can be given safely with regular doses of chemotherapy to attack cancer cells in two ways at the same time. This research is being done because it is not known if using Cyberknife with chemotherapy will be a safe way to treat pancreatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cyberknife radiation and gemcitabine | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cyberknofe and Gemcitabine
- description
- Cyberknife radiation and 6 cycles Gemcitabine
- interventionNames
- Radiation: Cyberknife radiation and gemcitabine
Primary outcomes (1)
- measure
- To demonstrate that radiation treatments can be reproduced as determined by evaluation of the prescription isodose curves
- timeFrame
- 10 days
Secondary outcomes (6)
- measure
- Acute and late toxicity as determined by patient self-reporting instruments that assess gastrointestinal side effects
- timeFrame
- 6 months
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically proven unresectable, non-metastatic pancreatic adenocarcinoma with measurable or evaluable disease and without involvement of the duodenum * Performance Status 0-2 * No prior anticancer therapy for pancreatic adenocarcinoma * No prior anticancer therapy of any kind within the last 5 years * Adequate hepatic, bone marrow, and renal function * Life expectance of \> 12 weeks * Women of childbearing potential must have a negative serum pregnancy test Exclusion Criteria: * Duodenal involvement of pancreatic cancer * Metastatic cancer * Active severe infection, or known chronic infection with HIV, hepatitis B virus, or hepatitis C virus * Cardiovascular disease including unstable angina, therapy for life-threatening ventricular arrhythmia, myocardial infarction, stroke, or congestive heart failure within the last 6 months * Life-threatening visceral disease or other severe concurrent disease * Pregnant or breastfeeding * Anticipated patient survival under 3 months * Another active malignancy within the past 5 years except for cervical cancer in situ, in situ carcinoma of the bladder or non-melanoma carcinoma of the skin.
References
Publications (0)
Data not yet available