Clinical trial · Interventional
Diamorphine or Alfentanil for Subcutaneous Use in Hospice In-patients?
An Open-label Pilot Comparison Between Alfentanil and Diamorphine for Palliative Care Patients Who Require Subcutaneous Opioids
NCT01049672CI-TRIAL-00017146DASHcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
OBJECTIVES: How does Alfentanil compare with the standard drug Diamorphine for subcutaneous analgesia in the palliative care setting? STUDY DESIGN: An open-label pilot comparison between alfentanil and diamorphine for palliative care patients who require subcutaneous opioids.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Alfentanil | Drug | — | UNRESOLVED |
| Diamorphine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Alfentanil
- description
- Hospice in-patients who require subcutaneous strong opioid administration will be given alfentanil
- interventionNames
- Drug: Alfentanil
- type
- ACTIVE_COMPARATOR
- label
- Diamorphine
- description
- Hospice in-patients who require strong opioids will be given diamorphine
- interventionNames
- Drug: Diamorphine
Primary outcomes (1)
- measure
- The change in MDAS will be calculated from day 0 to day 3 and compared between the two groups using a t-test if the data are sufficiently normally distributed, or the Mann-Whitney U test otherwise.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. To be thought by a hospice doctor to require parenteral strong opioids. 2. To have an estimated prognosis of less than 1 year. Exclusion Criteria: 1. Inability to read English sufficiently to be able to complete assessment questionnaires. 2. Confusion sufficient so that patient is unable to complete questionnaires. 3. Weakness or fatigue sufficient so that patient is unable to complete questionnaires. 4. Radiotherapy to source of pain in last 4 weeks. 5. Change in corticosteroid dose in last week.
References
Publications (0)
Data not yet available
No reference posted for this study.