Clinical trial · Interventional
Purple Grape Juice in Improving Vascular Health in Childhood Cancer Survivors
A Pilot Study to Evaluate the Effects of Purple Grape Juice on the Vascular Health of Childhood Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rationale: Survivors of childhood cancer are at an increased risk of developing cardiovascular risk factors as well as early cardiovascular disease, likely due to the intensive therapeutic regimen used to treat their cancer. Purple grape juice (PGJ) is a rich source of flavonoids and a powerful antioxidant. Clinical studies in both diseased and healthy adults suggest that daily consumption of PGJ contributes to increased antioxidant capacity, reduced low-density lipoprotein (LDL) oxidation, and improved vasodilation. Purpose: This randomized clinical trial is evaluating whether purple grape juice can reduce oxidative stress and improve the vascular health of survivors of childhood cancer in the early stages of cardiovascular disease.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Disease | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Apple Juice | Other | — | UNRESOLVED |
| Purple Grape Juice | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Purple Grape Juice First
- description
- After 4 week run-in period, drink 6 ounces of purple grape juice twice daily, then 4 week washout, week 12 drink 6 ounces of clear apple juice for 4 weeks twice daily
- interventionNames
- Other: Purple Grape Juice
- Other: Apple Juice
- type
- ACTIVE_COMPARATOR
- label
- Apple Juice First
- description
- After 4 week run-in period, drink 6 ounces of clear apple juice twice daily, then 4 week washout, week 12 drink 6 ounces of purple grape juice for 4 weeks twice daily
- interventionNames
- Other: Purple Grape Juice
- Other: Apple Juice
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with cancer \> 5 years ago * Off-maintenance therapy for \> 36 months * Age 10-30 years * Reside within a 50 mile radius of the University of Minnesota Exclusion Criteria: * Pregnant or planning to become pregnant * Start of oral contraceptives \< or = 3 months prior to study enrollment * Current smoker * Diabetes (type 1 and 2) * Antibiotic use \< 2 weeks prior to study enrollment
References
Publications (0)
Data not yet available