Dose Escalation Radiotherapy With Modulation of Intensity and Integrated Boost (SIB-IMRT) in the Treatment of Glioblastomas in Adults

Inclusion Criteria:

* Histopathologically proven diagnosis of glioblastoma (WHO grade IV astrocytoma)
* Diagnosis must be obtained by a stereotactic or surgical biopsy
* Age between 18 and 70
* Total or partial surgical resection deemed as not possible by a neurosurgeon
* OMS performance status 0 or 1
* Adequate blood function : absolute neutrophil count \> 1.5 x 109/L, platelets count \> 100 x 109/L platelets;
* Adequate liver function: bilirubin \< 1.5 ULN (upper limit of normal), ALT and AST \< 3 ULN,
* Adequate renal function: creatinine \< 1.5 ULN
* Patient must have been informed and must have signed the specific informed consent form.

Exclusion Criteria:

* other malignancy histology
* resection of the brain tumor complete on MRI exploration
* patient unable to give informed consent
* patient presenting counter-indication to MRI exploration
* patient must not have received neither radiotherapy nor chemotherapy for that affection
* concomitant malignancy
* patient already enrolled in another biomedical study with an experimental molecule
* pregnant, nursing woman, or without contraception
* private individuals of freedom or under tutelage (including legal guardianship)
* psychiatric, behavioural disorders or geographical situation precluding the administration or follow-up of the protocol (including claustrophobia)