Clinical trial · Observational
Human Papillomavirus on Oral Tissue, Saliva and Serum
Comparison of Detection of Human Papillomavirus on Tissue, Saliva and Serum
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Human papillomavirus (HPV) is one of the most prevalent infections in the world with several millions of new cases diagnosed yearly. Oral HPV infection may be associated with different diseases of oral cavities including some cases of oropharyngeal cancer. The aim of this report is to detect the presence of HPV DNA in samples of biopsies, oral swabs, saliva and serum of patient with oral squamous cell carcinoma (OSCC) and controls. We hoped to find there is correlation among the presence of HPV DNA in the several biological materials and if it is possible to use the saliva as screening to HPV DNA detection. The presence of tumor HPV DNA in blood may be of diagnostic and prognostic value.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- GROUP OSCC
- description
- The study group is composed by patients with a condition that requires a procedure/surgery for oral squamous cell carcinoma treatment. INTERVENTIONS: Collect blood, saliva and oral tissue.
- label
- CONTROL GROUP
- description
- Group without oral squamous cell carcinoma but with a condition that requires prosthetic procedure/surgery. INTERVENTIONS: Collect blood, saliva and oral tissue.
Primary outcomes (1)
- measure
- DNA HPV status (positive/negative)
- timeFrame
- six months
Secondary outcomes (1)
- measure
- clinical and pathological characteristics
- timeFrame
- six months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Pathological diagnosis of squamous cell carcinoma, presented lesions with primary site in the mouth or oropharynx; * Matched controls without a condition. Exclusion Criteria: * Patients that received radiotherapy.
References
Publications (2)
- BACKGROUNDBodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM, Zheng ZM. Could human papillomaviruses be spread through blood? J Clin Microbiol. 2005 Nov;43(11):5428-34. doi: 10.1128/JCM.43.11.5428-5434.2005. PMID 16272465
- BACKGROUNDZhao M, Rosenbaum E, Carvalho AL, Koch W, Jiang W, Sidransky D, Califano J. Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int J Cancer. 2005 Nov 20;117(4):605-10. doi: 10.1002/ijc.21216. PMID 15929076