Clinical trial · Interventional
Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
A Pilot Study for the LC-MS/MS Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage
NCT01038024CI-TRIAL-00009672completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the basis for the reported good effects of antioxidant supplementation. A blood test using Mass Spectrometry will measure DNA damage which is expected to decrease with antioxidant administration and therefore decrease the risk of cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1 tablet composed of antioxidants and minerals | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Antioxidant Supplements
- interventionNames
- Dietary Supplement: 1 tablet composed of antioxidants and minerals
Primary outcomes (1)
- measure
- To establish a base line level for 5 DNA modifications of White blood cells
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Health male or female non-melanoma patients or volunteers * 18 years or older with a life expectancy greater than 6 months * Willing to provide pre and post blood samples to measure five DNA modifications in white blood cells * Willing to participate in a one tablet a day eight week supplement program and to record the ingestion of the supplement on a participant calendar * Must have never smoked or has not smoked for at least 6 months * Informed of the investigational nature of the study, is able to provide informed consent and has signed thee informed consent form Exclusion Criteria: * Patients/healthy volunteers not meeting all of the above selection criteria. * Patients/healthy volunteers who have a history of kidney stones within the last 5 years. * Any participant with life threatening conditions including but not limited to cardiac failure, congestive heart failure, unstable coronary artery disease, uncontrolled hypertension, poorly controlled diabetes mellitus, kidney and liver disease,severe metabolic disorders and advanced cancer * Patients not willing to comply with protocol requirements
References
Publications (0)
Data not yet available
No reference posted for this study.