Clinical trial · Interventional
Does Inspection During Insertion Improve Adenoma Yields During Colonoscopy?
NCT01035775CI-TRIAL-00035833completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colonoscopy is not a perfect test. It misses a substantial number of neoplastic lesions and has some risk of missing cancer. Nearly all work on detection during colonoscopy has focused on the withdrawal phase of the examination. This randomized, controlled trial will compare the additional effect on the rate of adenoma detection of mucosal inspection during colonoscope insertion, with inspection during instrument withdrawal, in patients undergoing colonoscopy for colorectal cancer screening or surveillance.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Polyps | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Inspection during insertion | Procedure | — | UNRESOLVED |
| Inspection during withdrawal | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Insertion
- description
- Inspection on colonoscope insertion in addition to inspection during withdrawal from the cecum.
- interventionNames
- Procedure: Inspection during insertion
- type
- ACTIVE_COMPARATOR
- label
- Withdrawal
- description
- Inspection during withdrawal (usual care) without deliberate inspection during insertion.
- interventionNames
- Procedure: Inspection during withdrawal
Primary outcomes (1)
- measure
- Adenoma detection rate
- timeFrame
- During colonoscopy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 50 years * Patients undergoing colonoscopy for screening or surveillance indications Exclusion Criteria: * Previous surgical resection of all or part of the colon. * Inability to give informed consent. * Ulcerative colitis or Crohn's disease. * Polyposis syndrome or Lynch syndrome (HNPCC) * Any comorbid condition which the investigator deems would put the patient at increased risk from a slightly prolonged procedure
References
Publications (1)
- DERIVEDHewett DG, Rex DK. Inspection on instrument insertion during colonoscopy: a randomized controlled trial. Gastrointest Endosc. 2012 Aug;76(2):381-7. doi: 10.1016/j.gie.2012.04.454. PMID 22817789