Clinical trial · Interventional
An Immunonutritional Approach to the Prevention of Skin Cancer
The Effect of Omega-3 Polyunsaturated Fatty Acids on UV-induced Immunosuppression
NCT01032343CI-TRIAL-00011822completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Skin cancer incidence continues to rise and ultraviolet radiation (UVR) in sunlight is the principal cause. Solar UVR can promote cancer development through its ability to suppress the immune system. The purpose of this study is to determine whether dietary supplementation with omega-3 polyunsaturated fatty acids can protect human skin from UVR-induced immunosuppression.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Gelatine | Dietary Supplement | — | UNRESOLVED |
| Omega-3 PUFA | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Omega-3 PUFA capsule
- interventionNames
- Dietary Supplement: Omega-3 PUFA
- type
- PLACEBO_COMPARATOR
- label
- Gelatine capsule
- interventionNames
- Dietary Supplement: Gelatine
Primary outcomes (1)
- measure
- Degree of suppression of nickel-induced contact hypersensitivity
- timeFrame
- 3 months
- description
- Measurement of the erythema of nickel-induced eczema using a reflectance instrument
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pre-menopausal females * Sun-reactive skin type I / II * Reporting allergy to jewellery with nickel content Exclusion Criteria: * History of atopy * History of skin cancer * History of a photosensitivity disorder * Sunbathing (including sunbeds) in the last 3 months * Pregnancy * History of cardiac disease * Taking photoactive medicine * Not able to eat fish or gelatine * Taking fish oil supplements prior to the study
References
Publications (2)
- RESULTPilkington SM, Massey KA, Bennett SP, Al-Aasswad NM, Roshdy K, Gibbs NK, Friedmann PS, Nicolaou A, Rhodes LE. Randomized controlled trial of oral omega-3 PUFA in solar-simulated radiation-induced suppression of human cutaneous immune responses. Am J Clin Nutr. 2013 Mar;97(3):646-52. doi: 10.3945/ajcn.112.049494. Epub 2013 Jan 30. PMID 23364005
- DERIVEDPilkington SM, Rhodes LE, Al-Aasswad NM, Massey KA, Nicolaou A. Impact of EPA ingestion on COX- and LOX-mediated eicosanoid synthesis in skin with and without a pro-inflammatory UVR challenge--report of a randomised controlled study in humans. Mol Nutr Food Res. 2014 Mar;58(3):580-90. doi: 10.1002/mnfr.201300405. Epub 2013 Dec 5. PMID 24311515