Study of LBH589, A Deacetylase Inhibitor in Patients With Recurrent or Refractory Hodgkin or Non-Hodgkin's Lymphoma

Inclusion Criteria:

* Male or female patients age ≥ 18 years old with relapsed/refractory Hodgkin lymphoma or NHL patients who have relapsed or are refractory after receiving a minimum of two prior therapies
* Ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed

Laboratory requirements:

* ANC ≥ 1.5 x 10(9th)/L, unless due to bone marrow involvement with lymphoma
* Hemoglobin ≥ 9 g/dl without packed red blood cell dependency, unless due to bone marrow involvement with lymphoma
* Platelets ≥ 100 x 10(9th)/L, unless due to bone marrow involvement with lymphoma
* Serum creatinine ≤ 1.5 x Upper limit of Normal, or calculated Creatinine Clearance ≥ 50 mL/min
* AST and ALT ≤ 2.5 x Upper limit of Normal, unless due to liver involvement with lymphoma
* Serum bilirubin ≤ 1.5 x Upper limit of Normal
* Albumin \> 3.0 g/dl
* Serum potassium ≥ Lower limit of Normal
* Total serum calcium \[corrected for serum albumin\] or ionized calcium ≥ Lower limits of normal
* Serum magnesium ≥ Lower limit of Normal
* Serum phosphorus ≥ Lower limit of Normal
* TSH ≥ LLN and free T4 within normal limits. Patients are permitted to receive thyroid hormone supplements to treat underlying hypothyroidism.
* Baseline MUGA or ECHO must demonstrate LVEF ≥ 50%
* ECOG Performance Status of ≤ 2

Exclusion Criteria:

* Prior HDAC, DAC, HSP90 inhibitors or valproic acid for the treatment of cancer
* Patients who will need valproic acid for any medication during the study or within 5 days prior to first LBH589 treatment
* Peripheral neuropathy ≥ CTCAE grade 1
* Impaired cardiac function or clinically significant cardiac diseases, including any one of the following:
* Patients with congenital QT syndrome
* History or presence of sustained ventricular tachyarrhythmia.
* Any history of ventricular fibrillation or torsade de pointes
* Bradycardia defined as Heart Rate \< 50 bpm. Patients with pacemakers are eligible if Heart Rate ≥ 50 bpm
* Screening EKG with a QTc.450msec
* Right Bundle branch block + left anterior hemiblock (bifascicular block)
* Patients with myocardial infarction or unstable angina ≤ 6 months prior to starting study drug
* other clinically significant heart disease (e.g. CHF NY Heart Association class III or IV, uncontrolled hypertension, history of labile hypertension or history of poor compliance with an antihypertensive regimen)
* Impairment of GI function or GI disease that may significantly alter the absorption of LBH589
* Patients with Diarrhea \> CTCAE grade 1
* Other concurrent severe and/or uncontrolled medical conditions (e.g. uncontrolled diabetes or active or uncontrolled infection) including abnormal laboratory values that could cause unaccepted safety risks or compromise compliance with the protocol
* Patients using medications that have a relative risk of prolonging the QT interval or inducing torsade de pointes if treatment cannot be discontinued or switched to a different medication prior to starting study drug
* Concomitant use of CYP3A4 inhibitors
* Patients who have received targeted agents within 2 weeks or within 5 half-lives of the agent and active metabolites(which ever is longer) and who have not recovered from side effects of those therapies
* Patients who have received either immunotherapy within ≤ 8 weeks;chemotherapy within ≤ 4 weeks or radiation therapy to \>30% of marrow-bearing bone within ≤ weeks prior to starting study treatment or who have not yet recovered from side effects of such therapies
* Patients with an active bleeding tendency or is receiving any treatment with therapeutic doses of sodium warfarin or coumadin derivatives. Low doses of Coumadin (e.g.≤2 mg/day) to maintain line patency is allowed.
* Patients who have undergone major surgery ≤ 4 weeks prior to starting study drug or who have not recovered from side effects of such therapy
* Women who are pregnant or breast feeding or women of childbearing potential not using effective method of birth control
* Male patients whose sexual partners are women of childbearing potential not using effective birth control
* Patients with prior malignancy within 5 years (except for basal or squamous cell carcinoma, in situ cancer of the cervix or early stage prostate or bladder carcinomas)
* Patients with known positivity for HIV or hepatitis C: baseline testing for HIV and Hepatitis C is not required
* Prior allogenic stem cell transplant
* Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to him/her by the study staff
* Patients taking CYP2D6 inhibitors should be carefully monitored, but these drugs are not necessarily contraindicated when use concomitantly with LBH. Use of these drugs is not an exclusion criterion