Clinical trial · Interventional
PEACH Trial: Prescribed Exercise After Chemotherapy
Individually Prescribed Exercise Versus Usual Care in a Heterogeneous Cancer Survivor Population: A Pragmatic Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Many cancer survivors suffer symptoms such as fatigue and dyspnea which may persist for years or months after their chemotherapy has finished. Despite the known benefits of exercise and its potential to address many of the symptoms after cancer, the type of practical exercise programme which best suits this population is not known. Many exercise programmes performed in cancer survivors take place over many weeks or months and include people with specific types of cancer. Such programmes may therefore not be suitable for the majority of cancer survivors and would pose serious practical difficulties with high drop-out rates and expensive resource consumption if they were extended into clinical practice. We propose to run an 8-week exercise intervention in a mixed cancer population. Hypothesis: A brief, individually tailored 8-week intervention will increase fitness and improve other physical symptoms in a mixed cancer survivor population after chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise programme | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Exercise Programme
- description
- This will consist of an 8-week exercise programme, performed twice per week.
- interventionNames
- Behavioral: Exercise programme
- type
- PLACEBO_COMPARATOR
- label
- Usual Care
- description
- Standard practice including opportunistic exercise advice and patients' self-directed physical activity
- interventionNames
- Behavioral: Exercise programme
Primary outcomes (1)
- measure
- Modified Bruce Treadmill Test (Fitness)
- timeFrame
- 0, 8 weeks, 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of solid tumour and completion of adjuvant chemotherapy (and/or radiotherapy) with curative intent within the preceding 2-6 months. (Patients who have received neoadjuvant chemotherapy or chemoradiotherapy followed by surgery will also be eligible. In addition, patients continuing onto adjuvant hormone therapy and anti-Her2 directed therapy are eligible). * Ability to understand English * Willing to be randomised * Medical clearance to exercise * Age 21-69 * Fitness level average, fair or poor according to certain pre-determined cut-off points for age and gender(Fletcher et al., 2001) * Willing and able to attend supervised exercise sessions twice weekly for a period of 8 weeks, with an intention of achieving \> 90% attendance * LVEF \> 50% and not \< 20% worse than baseline in applicable patients Exclusion Criteria: * Evidence of active cancer * Chronic medical and orthopaedic conditions that would preclude exercise (eg uncontrolled congestive heart failure or angina, recent MI, breathing difficulties requiring oxygen use or hospitalization) * On beta-blocker medication * Prior history of another cancer in previous 5 years (exception: non-melanoma skin cancer and non-invasive cancer of the cervix) * Confirmed pregnancy * Dementia or psychiatric illness that would preclude ability to participate in study * Incomplete haematological recovery after chemotherapy (WCC\< 3, Hb \< 10 or Platelets \< 100) * BMI \> 35 * LVEF post chemotherapy \< 50% or \> 20% deterioration of baseline pre-systemic treatment. LVEF criteria are applicable in patients who have received chemotherapy deemed in normal clinical practice to have a potential effect LVEF and in whom the LVEF will have been measured before systemic treatment and at end of chemotherapy
References
Publications (1)
- BACKGROUNDWalsh JM, Hussey J, Guinan E, O' Donnell D. 'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': a feasibility study PEACH trial: prescribed exercise after chemotherapy. BMC Cancer. 2010 Feb 15;10:42. doi: 10.1186/1471-2407-10-42. PMID 20156345