Clinical trial · Observational
Evaluation of Radiation Induced Toxicity to the Heart by Multi-detector Computed Tomography (MDCT)
Evaluation of Radiation Induced Cardiotoxicity by Multi-detector Computed Tomography (MDCT)
NCT01018719CI-TRIAL-00002823unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The current study is aimed to evaluate various imaging methods, including multidetector computed tomography (MDCT) as potential surrogates to assess the degree of damage caused to the heart by radiation therapy to the breast, in breast cancer survivors many years before it becomes clinically apparent.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MDCT, ECG, Echocardiography | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Left side breast cancer
- interventionNames
- Device: MDCT, ECG, Echocardiography
- label
- Right side breast cancer
- interventionNames
- Device: MDCT, ECG, Echocardiography
Primary outcomes (1)
- measure
- Degree of damage to the coronary arteries as measured by MDCT
- timeFrame
- 5 to 15 years
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients who were diagnosed with early breast cancer, histologically proven. Both invasive and non invasive histologies will be included. 2. The study will include patients, who underwent a definitive surgery - either breast conserving or mastectomy - and received radiation therapy to the breast or to the chest wall respectively +/- to lymphatic drainage. 3. No evidence of recurrence of their malignancy or any other malignant disease. 4. Age at diagnosis and radiation to the breast will not exceed 60 years. 5. Signed informed consent by the patient will be mandatory. Exclusion Criteria: 1. As MDCT requires injection of contrast media, Patients with contra indications for injection of contrast media, due to either a history of allergic reaction or renal insufficiency, will be excluded of the study.
References
Publications (0)
Data not yet available
No reference posted for this study.