Clinical trial · Interventional
Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma
Multimodality Statistical Model of Early Response of High Grade Glioma to Radiation Therapy
NCT01018329CI-TRIAL-00008652completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying magnetic resonance imaging in response to radiation therapy in patients with high grade glioma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Diffusion Tensor Imaging | Procedure | — | UNRESOLVED |
| Diffusion-weighted magnetic resonance imaging | Procedure | — | UNRESOLVED |
| Dynamic Contract-Enhanced magnetic resonance imaging | Procedure | — | UNRESOLVED |
| Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Magnetic Resonance Spectroscopic Imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- I
- description
- Patients undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6 and then 4-6 weeks after completion of radiation therapy.Patients undergo MRI imaging at baseline, weeks 1, 2, 3, 5, 6 and then 6 weeks after radiation therapy.
- interventionNames
- Procedure: Magnetic Resonance Imaging
- Procedure: Diffusion Tensor Imaging
- Procedure: Magnetic Resonance Spectroscopic Imaging
- Procedure: Dynamic Contract-Enhanced magnetic resonance imaging
- Procedure: Diffusion-weighted magnetic resonance imaging
Primary outcomes (1)
- measure
- Early brain tumor response
Secondary outcomes (1)
- measure
- Early therapeutic-induced changes in normal surrounding brain
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients being treated for diagnosed with high grade glioma (WHO grade III or IV) at the University of Pennsylvania Medical Center who will be undergoing radiation therapy to the brain * Patient or legal representative able to provide written informed consent * Adult males and nonpregnant females Exclusion Criteria: * Vulnerable populations as specified (including pregnant patients, prisoners, patients with pacemakers or metallic implants) * Patients with renal failure * Patients with any condition considered a contraindication to MRI
References
Publications (0)
Data not yet available
No reference posted for this study.