Visualization of the Effect of Acupuncture on Brain Serotonin in Breast Cancer Survivors

Inclusion Criteria:

* History of Stage I, II, or III breast cancer for at least 12 months
* Have been seen by an oncologist within the previous 6-month period and determined to be free of disease by clinical examination and history
* Have been receiving endocrine therapy (tamoxifen or aromatase inhibitors for at least four weeks)
* Experienced hot flashes with a hot flash composite score of 5 or greater per day
* Hot flashes have been present for at least a month before study entry

Exclusion Criteria:

* Currently on chemotherapy or radiation therapy as adjuvant treatment
* Started with hormonal therapies such as tamoxifen or aromatase inhibitors within the last 4 weeks; or plan to change or terminate hormonal therapies in the next 14 weeks
* Any history of use of psychotropic medication such as SSRI use for the past 6 months
* Any past use of centrally acting medications such as clonidine for the past 6 months
* Any past diagnosis of a Major Depressive Episode within the last 6 months
* Any allergy to iodine or shell-fish or radio-nuclear materials
* Current use of estrogen and/or progestin
* Pregnancy
* Breast feeding
* Women of child-bearing potential NOT willing to use a medically acceptable form of contraception
* Current use of any anti-convulsant such as gabapentin
* History of cerebral infarction (including lacunar infarct with symptoms \>= 24 hours duration)
* History of Binswanger's disease (or a history of hypertensive encephalopathy)
* History of intracranial hemorrhage
* History of head trauma with loss of consciousness
* History of encephalitis
* History of extended exposure to known neurotoxin (e.g., cyanide, carbon monoxide)
* Uncontrolled metabolic disorder (e.g., thyroid disease, diabetes mellitus)
* History of normal pressure hydrocephalus
* History of Parkinson's or other basal ganglia disease
* History of substance abuse in the previous 6 months