Dasatinib, Bevacizumab, Paclitaxel in Patients With Advanced Malignancies

Inclusion Criteria:

1. Patients with advanced or metastatic cancer that is refractory to standard therapy, relapsed after standard therapy, or who have no standard therapy available that improves survival by at least three months.
2. Patients must be \>/= 3 weeks beyond treatment with a cytotoxic chemotherapy regimen, or therapeutic radiation, or major surgery. Patients may have received palliative localized radiation immediately before or during treatment providing radiation is not delivered to the only site of disease being treated under this protocol. After targeted/biologic therapy a patient has to be off treatment for 5 half-lives or 3 weeks whatever is shorter.
3. ECOG performance status \</= 2.
4. Patients must have normal organ and marrow function defined as: absolute neutrophil count \>/= 1,000/mL; platelets \>/=90,000/mL; creatinine \</= 2 X ULN; total bilirubin \</= 2.0; ALT(SGPT) \</= 5 X ULN; Exception for patients with liver metastasis: total bilirubin \</= 3 x ULN; ALT(SGPT) \</= 8 X ULN.
5. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 30 days after the last dose.
6. Patients must be able to understand and be willing to sign a written informed consent document.

Exclusion Criteria:

1. Uncontrolled intercurrent illness including, but not limited to, uncontrolled infection, uncontrolled asthma, need for hemodialysis, need for ventilatory support.
2. Patients with hemoptysis within 28 days prior to entering the study.
3. Patients with clinically significant unexplained bleeding within 28 days prior to the first dose of study medication.
4. Uncontrolled systemic vascular hypertension (systolic blood pressure \> 140mmHg, diastolic blood pressure \> 90mmHg on medication).
5. Patients with clinically significant cardiovascular disease: history of CVA within 6 months; myocardial infarction or unstable angina within 6 months.
6. Major surgery within 28 days prior to Day 1 of dosing Bevacizumab.
7. Pregnant or lactating women.
8. History of hypersensitivity to dasatinib or any component of the formulation.
9. History of hypersensitivity to bevacizumab, murine products, or any component of the formulation.
10. History of hypersensitivity to paclitaxel or any component of the formulation.
11. Patients with pleural effusion which is considered clinically significant by the attending physician.
12. Patients unwilling or unable to sign informed consent document.
13. Social situations that would limit compliance with study requirements.
14. Patients receiving opioids within 2 weeks before signing the consent and patients, who cannot be off opioids until initiating the study medication (for methylnaltrexone arm only).