Clinical trial · Interventional
In Vivo Confocal Microscopy Tumor Atlas Study
NCT01012154CI-TRIAL-00002769unknownPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to create an atlas based on the preliminary experience of the first feasibility study in neurosurgery. Hypothesis: That a confocal endomicroscope can be used during neurosurgery to provide in vivo histology that enables documentation of neurological pathology across a range of tumor ypes and grades, suitable for comparison with traditional histopathology from site-matched biopsies.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endomicroscope | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- All patients
- interventionNames
- Device: Endomicroscope
Primary outcomes (1)
- measure
- Generation of an atlas documenting the comparative features of in vivo microscopy versus traditional histopathology of site-matched biopsies across a range of tumor types and grades.
- timeFrame
- During surgery
Secondary outcomes (2)
- measure
- Test the ability of an expert neuropathologist to predict the outcome of biopsies based on the confocal images collected in vivo.
- timeFrame
- One week
- measure
- Capture usability and workflow aspects for the confocal device.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients with neurological pathology requiring surgery in which tumour resection might be evaluated by using biopsy Exclusion Criteria: * History of allergy to fluorescein * Patients on beta-blockers or ACE inhibitors * Pregnant women * Inability to give informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.