Clinical trial · Observational
Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
Genetic Polymorphisms in ALL Samples Submitted to Gene Array Analysis
NCT01005277CI-TRIAL-00059655completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study is looking at biomarkers in DNA samples from patients with acute lymphoblastic leukemia or acute myeloid leukemia. Studying samples of DNA from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 | Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11 | ONTOLOGY_EXACT | 0.98 |
| Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 | Adult Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 | ONTOLOGY_EXACT | 0.98 |
| Adult Acute Promyelocytic Leukemia With PML-RARA | Adult Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA | ALIAS | 0.90 |
| Childhood Acute Lymphoblastic Leukemia in Remission | Childhood Acute Lymphoblastic Leukemia | CURATED_BROADER | 0.78 |
| Childhood Acute Myeloid Leukemia | Childhood Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
| Childhood Acute Myeloid Leukemia in Remission | Childhood Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
| Recurrent Childhood Acute Lymphoblastic Leukemia | Childhood Acute Lymphoblastic Leukemia |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Ancillary-Correlative (genetic polymorphisms)
- description
- Previously collected DNA samples are analyzed for polymorphisms at a variety of loci. Gene expression and expression profiles are correlated with genotype and therapy outcomes.
- interventionNames
- Other: Laboratory Biomarker Analysis
Primary outcomes (7)
- measure
- Differences in induction outcome, dichotomized into complete remission or no remission
- timeFrame
- Up to 8 years
- description
- Assessed with Fisher's exact test.
- measure
- Differences in induction outcome, dichotomized into complete remission or no remission
- timeFrame
- Up to 8 years
- description
- Assessed with Pearson's chi square statistic test
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * DNA samples available from patients meeting the following criteria: * Infants with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) * Patients with pre-B ALL, including responders vs non-responders in selected genotypes \[hyperdiploid, hypodiploid, t(12;21), t(9;22), t(1;19), and t(4;11)\] and responders and non-responders regardless of genotype * Pediatric patients with AML registered on POG-9421 * Adult patients with ALL, including t(8.21), inv(16), t(15;17), complex cytogenetics, and secondary AML * Pediatric patients with relapsed ALL enrolled on COG-AALL01P2 * Pediatric patients enrolled on COG-9900 and other CCG or POG trials
References
Publications (0)
Data not yet available
No reference posted for this study.