Clinical trial · Interventional
Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer
Randomised Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer (RESTORE-AIR)
NCT01003522CI-TRIAL-00002739RESTORE-AIRunknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate whether the use of airways stents (metal tubes to open and keep open narrowed airways) together with the standard treatment increases the proportion of patients who can complete a 6min walking distance (6MWD) test at 2 weeks +/- 2days in patients with breathlessness due to lung cancer, when compared to standard treatment alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Arterial puncture | Other | — | UNRESOLVED |
| Biopsy material | Other | — | UNRESOLVED |
| General anaesthetic | Procedure | — | UNRESOLVED |
| Inpatient stays | Procedure | — | UNRESOLVED |
| Spirometry & flow volume loop assessment | Other | — | UNRESOLVED |
| Venepuncture | Other | — | UNRESOLVED |
| Walking test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Treatment Arm A
- description
- Stenting of central lesion and subsequent standard palliative treatment and dyspnoea symptom control
- interventionNames
- Other: Arterial puncture
- Other: Venepuncture
- Procedure: General anaesthetic
- Procedure: Inpatient stays
- Other: Walking test
- Other: Spirometry & flow volume loop assessment
- Other: Biopsy material
- type
- OTHER
- label
- Treatment Arm B
- description
- Standard palliative treatment and standard dyspnoea symptom control.
- interventionNames
- Other: Arterial puncture
- Other: Venepuncture
- Other: Walking test
- Other: Spirometry & flow volume loop assessment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Able to give informed written consent in the English language * Able and willing to attend St Georges Hospital / Royal Marsden Hospital for stent insertion (if allocated) and documentation of 6 minute walking distance. * Willing to re-attend for follow-up and 6 minute walking distance at St Georges Hospital / Royal Marsden Hospital 2 weeks later (all patients) * Diagnosis of non-small cell lung cancer with centrally placed tumour with some degree of airway obstruction from information from bronchoscopy or CT scan. * ECOG Performance status: 0-3 Exclusion Criteria: * Relative contraindications to stenting, e.g. bleeding abnormality or anticoagulation problems. * Pregnancy * Radically treatable disease.
References
Publications (0)
Data not yet available
No reference posted for this study.