Clinical trial · Observational
An Exploration of Genetic Testing for Prostate Cancer Susceptibility
An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
NCT00997464CI-TRIAL-00002721unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale)
Secondary outcomes (4)
- measure
- Why are men interested/ not interested in seeking genetic profiling for prostate cancer, and what might be the uptake of such testing?
- measure
- What are the expectations of this testing from the perspective of the user, what are the perceived benefits and limitations of testing and how do these change through the testing process
- measure
- Is there a relationship between a family history of cancer, cancer worry, and a persons intention to seek genetic testing?
- measure
- How would the information provided by such a test be used by the individual and the family and how could this impact upon the healthcare system
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria: * Men with a positive family history of prostate cancer. The definition of a positive family history will be: Men with a first degree relative with prostate cancer diagnosed at \<70 years; Men with two relatives with prostate cancer where at least on is diagnosed at \<70 years; Men with three relatives with prostate cancer diagnosed at any age * Age 40-69 years * No previous biopsy for raised PSA * Absence of any psychological, familial, sociological or geographic situation potentially hampering compliance with the study protocol and follow-up schedule. Exclusion Criteria: * Previous prostate cancer * Men from families where there is known to be a mutation in a high-risk prostate cancer gene * Men who have had a prostate biopsy within the last 12 months.
References
Publications (0)
Data not yet available
No reference posted for this study.