Clinical trial · Interventional
Processed Meat and Colon Carcinogenesis
Effect of Processed Meat on Colorectal Carcinogenesis. Study of Mechanisms. Choice of Preventive Strategies
NCT00994526CI-TRIAL-00008681HemcancercompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer kills forty five people in France every day. Epidemiological studies suggest that two cases out of three could be prevented and show that processed meat intake is a consistent risk factor. The aim of this study is to understand how meat promotes cancer, to find protective strategies, and to make compelling dietary recommendations.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ham | Other | — | UNRESOLVED |
| Ham + calcium | Other | — | UNRESOLVED |
| Ham + vitamin E | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Ham
- interventionNames
- Other: Ham
- type
- EXPERIMENTAL
- label
- Ham + calcium
- interventionNames
- Other: Ham + calcium
- type
- EXPERIMENTAL
- label
- Ham + vitamin E
- interventionNames
- Other: Ham + vitamin E
Primary outcomes (1)
- measure
- Urinary biomarker (DHN-MA:dihydroxynonene mercapturic acid), will be measured before and after every interventional period
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Male * Body mass index 20 \<= BMI \<= 30 kg/m2 * Affiliated to French National Health Insurance * Subject giving his written informed consent * Subject considered as normal after clinical examination and medical questionnaire Exclusion Criteria: * Positive serologies to HIV or HCV, determined on blood samples * Previous medical and/or surgery judged by the investigator as incompatible with this study * Previous familial of colon, ovarian or breast cancer * Chronic pathologies : cardiovascular diseases, cancer, chronic inflammation diseases, renal, intestinal impairments * Dislike ham * Heavy consumer of alcohol * Practising intensive physical exercise * Being under someone's supervision * Refusal to be registered on the National Volunteers Data file * Dietary habits unreliable to controlled food intake * Being in exclusion on the National Volunteers Data file
References
Publications (1)
- DERIVEDPierre FH, Martin OC, Santarelli RL, Tache S, Naud N, Gueraud F, Audebert M, Dupuy J, Meunier N, Attaix D, Vendeuvre JL, Mirvish SS, Kuhnle GC, Cano N, Corpet DE. Calcium and alpha-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers. Am J Clin Nutr. 2013 Nov;98(5):1255-62. doi: 10.3945/ajcn.113.061069. Epub 2013 Sep 11. PMID 24025632